Publications

Acute ischemic stroke thrombi have an outer shell that impairs fibrinolysis

Acute ischemic stroke thrombi have an outer shell that impairs fibrinolysis In Neurology | Volume 93, Number 18 published on May, 29th 2019 Authors Lucas Di Meglio, MD, Jean-Philippe Desilles, MD, PhD, Véronique Ollivier, PhD, Mialitiana Solo Nomenjanahary, MSci, Sara Di Meglio, MSci, Catherine Deschildre, MSci, Stéphane Loyau, MSci, Jean-Marc Olivot, MD, PhD, Raphael Blanc, […]
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Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab

Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab First-in-Human Healthy Volunteer Trial In Arteriosclerosis, Thrombosis, and Vascular Biology; 2019; Vol 39 Issue 5; 956-964. Published on April 25th, 2019 Authors Christine Voors-Pette, Kristell Lebozec, Peter Dogterom, Laurie Jullien, Philippe Billiald, Pauline Ferlan, Lionel Renaud, Olivier Favre-Bulle, Gilles Avenard, Matthias […]
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Quality and cost assessment of a recombinant antibody fragment produced from mammalian, yeast and prokaryotic host cells: A case study prior to pharmaceutical development

Quality and cost assessment of a recombinant antibody fragment produced from mammalian, yeast and prokaryotic host cells: A case study prior to pharmaceutical development In New Biotechnology, 2018 Authors Kristell Lebozec, Martine Jandrot-Perrus, Gilles Avenard, Olivier Favre-Bulle, and Philippe Billiald. Abstract Monoclonal antibody fragments (Fab) are a promising class of therapeutic agents. Fabs are aglycosylated […]
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Immobilized fibrinogen activates human platelets through glycoprotein VI

Immobilized fibrinogen activates human platelets through glycoprotein VI In Haematologica 2018 Volume 103(5):898-907, published on Feb, 22nd 2018 Authors Pierre H Mangin, Marie-Blanche Onselaer,  Nicolas Receveur, Nicolas Le Lay,  Alexander T Hardy, Clare Wilson, Ximena Sanchez, Stéphane Loyau, Arnaud Dupuis, Amir K Babar, Jeanette LC Miller, Helen Philippou, Craig E Hughes, Andrew B Herr, Robert AS […]
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Design, development and characterization of ACT017, a humanized Fab that blocks platelet’s glycoprotein VI function without causing bleeding risks

Design, development and characterization of ACT017, a humanized Fab that blocks platelet’s glycoprotein VI function without causing bleeding risks In mAbs, 2017, VOL. 0, NO. 0, 1–14, published on Jun, 9th 2017 Authors Kristell Lebozec, Martine Jandrot-Perrus, Gilles Avenard, Olivier Favre-Bulle, and Philippe Billiald. Abstract Glycoprotein VI is a platelet-specific collagen receptor critical for in […]
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International Journal of Stroke: Beyond antiplatelets: The role of glycoprotein VI in ischemic stroke

Beyond antiplatelets: The role of glycoprotein VI in ischemic stroke In International Journal of Stroke 0(0) 1–8, published on May, 2016 Authors Isuru Induruwa1, Stephanie M Jung2 and Elizabeth A Warburton1 Abstract Background: Platelets are essential to physiological hemostasis or pathological thrombus formation. Current antiplate- let agents inhibit platelet aggregation but leave patients at risk of systemic […]
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