Acute ischemic stroke thrombi have an outer shell that impairs fibrinolysis In Neurology | Volume 93, Number 18 published on May, 29th 2019 Authors Lucas Di Meglio, MD, Jean-Philippe Desilles, MD, PhD, Véronique Ollivier, PhD, Mialitiana Solo Nomenjanahary, MSci, Sara Di Meglio, MSci, Catherine Deschildre, MSci, Stéphane Loyau, MSci, Jean-Marc Olivot, MD, PhD, Raphael Blanc, […]
Publications
April 25, 2019
Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab
Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab First-in-Human Healthy Volunteer Trial In Arteriosclerosis, Thrombosis, and Vascular Biology; 2019; Vol 39 Issue 5; 956-964. Published on April 25th, 2019 Authors Christine Voors-Pette, Kristell Lebozec, Peter Dogterom, Laurie Jullien, Philippe Billiald, Pauline Ferlan, Lionel Renaud, Olivier Favre-Bulle, Gilles Avenard, Matthias […]
April 26, 2018
Quality and cost assessment of a recombinant antibody fragment produced from mammalian, yeast and prokaryotic host cells: A case study prior to pharmaceutical development
Quality and cost assessment of a recombinant antibody fragment produced from mammalian, yeast and prokaryotic host cells: A case study prior to pharmaceutical development In New Biotechnology, 2018 Authors Kristell Lebozec, Martine Jandrot-Perrus, Gilles Avenard, Olivier Favre-Bulle, and Philippe Billiald. Abstract Monoclonal antibody fragments (Fab) are a promising class of therapeutic agents. Fabs are aglycosylated […]
February 22, 2018
Immobilized fibrinogen activates human platelets through glycoprotein VI
Immobilized fibrinogen activates human platelets through glycoprotein VI In Haematologica 2018 Volume 103(5):898-907, published on Feb, 22nd 2018 Authors Pierre H Mangin, Marie-Blanche Onselaer, Nicolas Receveur, Nicolas Le Lay, Alexander T Hardy, Clare Wilson, Ximena Sanchez, Stéphane Loyau, Arnaud Dupuis, Amir K Babar, Jeanette LC Miller, Helen Philippou, Craig E Hughes, Andrew B Herr, Robert AS […]
January 20, 2018
Design, development and characterization of ACT017, a humanized Fab that blocks platelet’s glycoprotein VI function without causing bleeding risks
Design, development and characterization of ACT017, a humanized Fab that blocks platelet’s glycoprotein VI function without causing bleeding risks In mAbs, 2017, VOL. 0, NO. 0, 1–14, published on Jun, 9th 2017 Authors Kristell Lebozec, Martine Jandrot-Perrus, Gilles Avenard, Olivier Favre-Bulle, and Philippe Billiald. Abstract Glycoprotein VI is a platelet-specific collagen receptor critical for in […]
May 3, 2016
International Journal of Stroke: Beyond antiplatelets: The role of glycoprotein VI in ischemic stroke
Beyond antiplatelets: The role of glycoprotein VI in ischemic stroke In International Journal of Stroke 0(0) 1–8, published on May, 2016 Authors Isuru Induruwa1, Stephanie M Jung2 and Elizabeth A Warburton1 Abstract Background: Platelets are essential to physiological hemostasis or pathological thrombus formation. Current antiplate- let agents inhibit platelet aggregation but leave patients at risk of systemic […]